Effect of poly-herbal formulation in experimentally induced diabetic nephropathy in rats
Keywords:
Diabetic renal damage, Nephropathy,, Proteinuria, Anti-oxidant, Serum creatinine, PHF (Polyherbal formulation).Abstract
Introduction: Failure of kidney due to diabetes mellitus (DM) is a major outcome affecting around 25% of patients. In present times treatments related to diabetic kidney disease does not serves to its best with complications. Thus rationale for ongoing study was to scout the benefits of polyherbal formulation (PHF) in the disease condition.
Objectives: Study was to understand the hydroalcoholic extract of Withania somnifera (leaves), Juniperus communis (barries) and Tinespora cordifolia (stem) for Kidney protective effect in streptozotocin (STZ) and Nicotinamide (NA) induced diabetic nephropathy (DN) in rats.
Materials and Methods: Male diabetes Wistar species were grouped in five, Normal control (NC), Disease control (DC), standard control (Metformine 70 mg/kg, p.o), T1 (Polyherbal formulation 100 mg/kg, p.o.) and T2 (Polyherbal formulation 200 mg/kg, p.o). the regime was or 6 weeks and biochemical investigations were carried out followed by histopathology of the kidney.
Results: Animals without treatments were severely hyperglycemia with renal function. Animals of standard and Polyherbal formulation (PHF) groups developed significantly lower plasma glucose levels, and normal dropping volumes indicating a significant loop filtration rate. Decrease in proteinuria, creatinine and Bilirubin levels were observed as that of untreated animals.
Conclusion: On administration with PHF the effect was beneficial on DN and thus, improvement of renal function parameters was observed.
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