The Influence of polymers on Physicochemical Properties and Invitro Release of Erlotinib loaded nanomicelles: Development and characterization

Authors

  • Shruti Patel Ph.D. Research Scholar, Department of Pharmaceutics, Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India-391760
  • Asha Patel Associate Professor, Department of Pharmaceutics, Parul Institute of Pharmacy, Parul University, Vadodara, Gujarat, India-391760

Keywords:

Pharmaceutics

Abstract

Erlotinib is epidermal growth factor receptor inhibitor (EGFR) used as first line therapy for treatment of non-small cell lung cancer. However, there are certain limitation which limits its use. To overcome that we have formulated erlotinib polymeric micelles. This study has investigated erlotinib loaded Pluronic F68, Pluronic F127 and TPGS polymeric micelles for micellar size, critical micelles concentration, entrapment efficiency, drug loading and In vitro drug release. Micellar size and PDI is characterise by dynamic light scattering. From results we investigated tocopherol polyethylene glycol has small micelles size in the range of 55nm-90nm compared to Pluronic F127 and Pluronic F68. Moreover,entrapment and drug loading were significantly increases to 69.2% by formulating TPGS micelles. In vitro drug release data predicts TPGS releases the drug in more sustain manner compared to Pluronic polymeric micelles. In nutshell, TPGS micelles would be platform delivery for targeting anticancer agents.

References

. Wang Y, Zhou C, Schmid Bindert G. Erlotinib in the treatment of advanced non-small cell lung cancer: An update for clinicians. Ther Adv Med Oncol. 2012;4(1):19–29.

. Wee P, Wang Z. Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways. Cancers (Basel). 2017 May 17;9(5):52.

. Park JH, Liu Y, Lemmon MA, Radhakrishnan R. Erlotinib binds both inactive and active conformations of the EGFR tyrosine kinase domain. Biochem J. 2012 Dec 15;448(3):417-23.

. Abdelgalil AA, Al-Kahtani HM, Al-Jenoobi FI. Erlotinib. Profiles of Drug Substances, Excipients, and Related Methodology. 2020;45:93-117.

. Patricia A Tang, Ming-Sound Tsao & Malcolm J Moore. A review of erlotinib and its clinical use. Expert Opinion on Pharmacotherapy. 2006; 7; 2:177-193.

. Qi P. Nanoparticulate systems for drug delivery. Adv Drug Deliv. 2002;22854402(1):1–5.

. Allen C, Maysinger D, Eisenberg A. Nano-engineering block copolymer aggregates for drug delivery Christine. Colloids and Surfaces. 1999;16(1):3–27.

. Shaarani S, Hamid SS, Mohd Kaus NH. The Influence of Pluronic F68 and F127 Nanocarrier on Physicochemical Properties, In vitro Release, and Antiproliferative Activity of Thymoquinone Drug. Pharmacognosy Res. 2017 Jan-Mar;9(1):12-20.

. Akbar MU, Zia KM, Nazir A, Iqbal J, Ejaz SA, Akash MSH. Pluronic-Based Mixed Polymeric Micelles Enhance the Therapeutic Potential of Curcumin. AAPS PharmSciTech. 2018 Aug;19(6):2719-2739.

. Kulthe SS, Choudhari YM, Inamdar NN, Mourya V. Polymeric micelles: Authoritative aspects for drug delivery. Des Monomers Polym. 2012;15(5):465–521.

. Biswas S, Kumari P, Lakhani PM, Ghosh B. Recent advances in polymeric micelles for anti-cancer drug delivery. European Journal of Pharmaceutical Sciences.2016(83): 184–202.

. Kabanov AV, Batrakova EV, Alakhov VY. Pluronic block copolymers as novel polymer therapeutics for drug and gene delivery. J Control Release. 2002 Aug 21;82(2-3):189-212.

. Kabanov AV, Batrakova EV, Miller DW. Pluronic block copolymers as modulators of drug efflux transporter activity in the blood-brain barrier. Adv Drug Deliv Rev. 2003 Jan 21;55(1):151-64.

. Niu J, Yuan M, Chen C, Wang L, Tang Z, Fan Y, Liu X, Ma YJ, Gan Y. Berberine-Loaded Thiolated Pluronic F127 Polymeric Micelles for Improving Skin Permeation and Retention. Int J Nanomedicine. 2020 Dec 8; 15:9987-10005.

. Wang H, Williams GR, Wu J, Wu J, Niu S, Xie X, Li S, Zhu LM. Pluronic F127-based micelles for tumor-targeted bufalin delivery. Int J Pharm. 2019 Mar 25;559:289-298.

. Kabanov AV, Batrakova EV, Alakhov VY. Pluronic block copolymers for overcoming drug resistance in cancer. Adv Drug Deliv Rev. 2002 Sep 13;54(5):759-79.

. Zuccari G, Baldassari S, Alfei S, Marengo B, Valenti GE, Domenicotti C, Ailuno G, Villa C, Marchitto L, Caviglioli G. D-α-Tocopherol-Based Micelles for Successful Encapsulation of Retinoic Acid. Pharmaceuticals. 2021; 14(3):212

. Jain S, Pandey S, Sola P, Pathan H, Patil R, Ray D, et al. Solubilization of Carbamazepine in TPGS Micelles: Effect of Temperature and Electrolyte Addition. AAPS PharmSciTech. 2019;20(5):1–8.

. Zhang Y, Jin T, Zhuo RX. Methotrexate-loaded biodegradable polymeric micelles: Preparation, physicochemical properties and in vitro drug release. Colloids Surfaces B Biointerfaces. 2005;44(2–3):104–9.

. Li H, Yan L, Tang EKY, Zhang Z, Chen W, Liu G, et al. Synthesis of TPGS / Curcumin Nanoparticles by Thin-Film Hydration and Evaluation of Their Anti-Colon Cancer Efficacy In Vitro and In Vivo.Frontiers in Pharmacology . 2019;10:1–12.

. Song Y, Liu D, Cheng Y, Liu M, Ye W, Zhang B. Dual subcellular compartment delivery of doxorubicin to overcome drug resistant and enhance antitumor activity. Nat Publ Gr. 2015:1–19.

. Suksiriworapong J, Rungvimolsin T, A-gomol A, Junyaprasert VB, Chantasart D. Development and characterization of lyophilized diazepam-loaded polymeric micelles. AAPS PharmSciTech. 2014 Feb;15(1):52-64.

. Bolandnazar S, Divsalar A, Valizadeh H, Khodaei A, Zakeri-Milani P. Development and application of an HPLC method for erlotinib protein binding studies. Adv Pharm Bull. 2013;3(2):289–93.

. Topel Ö, Çakir BA, Budama L, Hoda N. Determination of critical micelle concentration of polybutadiene-block- poly(ethyleneoxide) diblock copolymer by fluorescence spectroscopy and dynamic light scattering. J Mol Liq. 2013;177:40–3.

. Rupp C, Steckel H, Müller BW. Solubilization of poorly water-soluble drugs by mixed micelles based on hydrogenated phosphatidylcholine. Int J Pharm. 2010;395(1–2):272–80.

. Cai Y, Wang S, Wu M, Tsosie JK, Xie X, Wan J, et al. PCL-F68-PCL/PLGA-PEG-PLGA mixed micelles mediated delivery of mitoxantrone for reversing multidrug resistant in breast cancer. RSC Adv. 2016;6(42):35318–27.

. Chu B, Shi S, Li X, Hu L, Shi L, Zhang H, et al. Preparation and evaluation of teniposide-loaded polymeric micelles for breast cancer therapy. Int J Pharm. 2016;513(1–2):118–29.

. Venkateswarlu V, Manjunath K. Preparation, characterization and in vitro release kinetics of clozapine solid lipid nanoparticles. J Control Release. 2004;95(3):627–38.

. Pires PAR. Thermodynamics of micellization of cationic surfactants in aqueous solutions : consequences of the presence of the 2-acylaminoethyl moiety in the surfactant head group.Langmuir. 2004;(January):9551–9559

. Sadoqi M, Lau-cam CA, Wu SH. Journal of Colloid and Interface Science Investigation of the micellar properties of the tocopheryl polyethylene glycol succinate surfactants TPGS 400 and TPGS 1000 by steady state fluorometry. J Colloid Interface Sci. 2009;333(2):585–9.

. Rassing J. Ultrasonic velocity and light-scattering studies on the polyoxyethylene-polyoxypropylene copolymer Pluronic F127 in aqueous solution. International Journal of Pharmaceutics.1983;3:47–55.

. Patil S, Ujalambkar V, Rathore A, Rojatkar S, Pokharkar V. Biomedicine & Pharmacotherapy Galangin loaded galactosylated Pluronic F68 polymeric micelles for liver targeting. Biomed Pharmacother. 2019;112(February):108691.

. Soliman WE, Shehata TM, Mohamed ME, Younis NS, Elsewedy HS. Enhancement of Curcumin Anti-Inflammatory Effect via Formulation into Myrrh Oil-Based Nanoemulgel. Polymers (Basel). 2021 Feb 14;13(4):577.

. Sahu A, Kasoju N, Goswami P, Bora U. Encapsulation of curcumin in Pluronic block copolymer micelles for drug delivery applications. J Biomater Appl. 2011 Feb;25(6):619-39.

. Butt AM, Amin MCIM, Katas H, Sarisuta N, Witoonsaridsilp W, Benjakul R. In vitro characterization of Pluronic F127 and D-α-tocopheryl polyethylene glycol 1000 succinate mixed micelles as nanocarriers for targeted anticancer-drug delivery. J Nanomater. 2012;2012.

. Alexandridis P, Alan Hatton T. Poly(ethylene oxide)poly(propylene oxide)poly(ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: thermodynamics, structure, dynamics, and modeling. Colloids Surfaces A Physicochem Eng Asp. 1995;96(1–2):1–46.

. Sezgin Z, Yüksel N, Baykara T. Preparation and characterization of polymeric micelles for solubilization of poorly soluble anticancer drugs. Eur J Pharm Biopharm. 2006 Nov;64(3):261-8.

Additional Files

Published

2022-11-23

How to Cite

Patel , S., & Patel , A. (2022). The Influence of polymers on Physicochemical Properties and Invitro Release of Erlotinib loaded nanomicelles: Development and characterization. Parul University Journal of Health Sciences and Research, 1(1), 5–13. Retrieved from https://pujhsr.paruluniversity.ac.in/index.php/home/article/view/5

Issue

Vol. 1 No. 1 (2022): Inaugural Issue

Section

Research Articles

License

Copyright (c) 2022 Shruti Patel , Asha Patel

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

The contents of PUJHSR are protected under Indian and international copyrights. However, the journal contents are free for non-commercial purpose under the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported License (https://creativecommons.org/licenses/by-nc-sa/4.0/).