The Influence of polymers on Physicochemical Properties and Invitro Release of Erlotinib loaded nanomicelles: Development and characterization
Erlotinib is epidermal growth factor receptor inhibitor (EGFR) used as first line therapy for treatment of non-small cell lung cancer. However, there are certain limitation which limits its use. To overcome that we have formulated erlotinib polymeric micelles. This study has investigated erlotinib loaded Pluronic F68, Pluronic F127 and TPGS polymeric micelles for micellar size, critical micelles concentration, entrapment efficiency, drug loading and In vitro drug release. Micellar size and PDI is characterise by dynamic light scattering. From results we investigated tocopherol polyethylene glycol has small micelles size in the range of 55nm-90nm compared to Pluronic F127 and Pluronic F68. Moreover,entrapment and drug loading were significantly increases to 69.2% by formulating TPGS micelles. In vitro drug release data predicts TPGS releases the drug in more sustain manner compared to Pluronic polymeric micelles. In nutshell, TPGS micelles would be platform delivery for targeting anticancer agents.
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